Killing of human being is one of the most serious of major crimes. Since very long times laws were framed by different judicial authority in a bit to prevent its further occurrence. Inspite of all, there has been a phenomenal rise in the incidence of homicide all over the world including Nepal, perhaps due to a highly intensified struggle for survival in the face of fast industrialization and urbanization. Murder is most often impulsive, violent & explosive act.Revenge, quarrel, anger, jealousy, loss of prestige etc. have been the real motives leading to the worst and most dreaded act of homicide all over the world throughout the ages. Homicide or killing of a fellow human being therefore has been a perennial phenomenon either in form of human sacrifices or mass-massacres in wars or killing of a particular individual here and there actuated by personal motive whether offensive or defensive. Parameters of epidemiology like age, sex, occupation, educational status, socio-economic status of the victim & the assailant, parameters of incidence like place, causes & intention of homicide were studied & medico-legal autopsy findings and opinion about fatality causation has been made.